Nurse guide for subcutaneous trastuzumab administration. Product identifier product name herceptin r vials 440 mg product code sap10086840 synonyms herceptin. Herceptin hylecta trastuzumab and hyaluronidaseoysk fda. Trastuzumab, sold under the brand name herceptin among others, is a monoclonal antibody used to treat breast cancer. Permanently discontinue herceptin for a persistent 8 weeks lvef decline or for suspension of herceptin. Kadcyla her2positive breast cancer diseases market to 2023 is the property of its rightful owner. Subcutaneous formulation of roches herceptin approved in.
Herceptin trastuzumab is a recombinant dnaderived humanized monoclonal antibody that selectively binds with high affinity in a cellbased assay kd 5 nm to the extracellular domain of the human epidermal growth factor receptor 2 protein, her2. Monoclonal antibody trastuzumab herceptin is considered as frontline therapy for her2positive breast cancer patients. One week after the last weekly dose of herceptin, administer 6 mgkg as an iv infusion over 30. To insert a pdf file as an object into a powerpoint presentation, you make it available to those youre sharing the presentation with. Infusion reactions are a common side effect most of which are mild and easily managed, anaphylaxis occurs rarely. Page 1 of 36 highlights of prescribing information these highlights do not include all the information needed to use perjeta safely and effectively. Herceptin trastuzumab, herceptin hylecta trastuzumab and. It also induces apoptosis through antibodydependent cellular cytotoxicity. Trastuzumab herceptin american journal of neuroradiology.
Herceptin and its biosimilars effects have been shown to be preferentially. Qualitative and quantitative composition herceptin sc vial contains 600mg5ml of trastuzumab. Herceptin sc190507 1 australian product information herceptin sc trastuzumab solution for injection 1. Most cancer therapeuticsincluding cytotoxic agents and biologicscarry a risk for infusion reactions, which vary in symptom severity from mild flushing to potentially life.
From here, you can crop your screenshot, resize it, and position it. Unfortunately, inserting pdf content is not possible when editing a presentation in powerpoint for the web. Managing premedications and the risk for reactions to. Some of these precautions and warnings include the potential risk of the drug causing congestive heart failure, the safety of taking the drug when pregnant or breastfeeding, and the possibility of the drug causing infusion reactions. Since 1998, herceptin has been used to treat more than 1. In europe, the summary of product characteristics smpc describes.
Sep 30, 2019 herceptin may be resumed if, within 48 weeks, the lvef returns to normal limits and the absolute decrease from baseline is. Ppt kadcyla her2positive breast cancer diseases market. Trastuzumab in the treatment of metastatic breast cancer. To keep a pdf file as a support document for your presentation insert the entire pdf into. Reconstitution with only 20 ml of the supplied bacteriostatic water for injection bwfi, usp, containing 1. Ppt kadcyla her2positive breast cancer diseases market to. Herceptin is a her2neu receptor antagonist indicated for. Kadcyla ado trastuzumab is roches third her2targeted mab, approved by the fda in february 20, by the japanese mhlw in september 20, and by the ema in.
Life expectancy for these people could be calculated by adding up the mean time. Herceptin is a monoclonal antibody that binds to the extracellular portion of the her2 gene, preventing dimerization and the cascade that leads to the expression of growth factors. To keep a pdf file as a support document for your presentation insert the entire pdf into the presentation as an object that you can open and view during your presentation. Highlights of prescribing information these highlights do not include all the information needed to use empliciti safely. It is specifically used for breast cancer that is her2 receptor positive. It is usually given as an adjuvant therapy after the main treatment, such as surgery. Jan 31, 2015 herceptin is a drug used as adjuvant chemotherapy in cancer slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Sep 30, 2019 herceptin trastuzumab kit herceptin trastuzumab injection, powder, lyophilized, for solution if this spl contains inactivated ndcs listed by the fda initiated compliance action, they will be specified as such. Trastuzumab cures cancer and disrupts the practice of. Clinical trials of herceptin trastuzumab european journal of. Although these three categories are described separately, there is overlap between definitions. Taxol paclitaxel injection is a clear, colorless to slightly yellow viscous solution.
Herceptin is used to treat cancer by affecting the cancer cells ability to grow and multiply. For marketed products discussed in this presentation, please see full prescribing information on our website all mentioned. Do not substitute herceptin trastuzumab for or with adotrastuzumab emtansine. Incidence, risk factors, and management of infusion. Infusion reactions are a common side effect most of which are mild and easily managed, anaphylaxis. Mar 27, 2014 monoclonal antibody trastuzumab herceptin is considered as frontline therapy for her2positive breast cancer patients. Trastuzumab herceptin is used in neoadjuvant, adjuvant and metastatic breast cancer. Ppt hot topic presentation i want herceptin powerpoint. The package insert of the diagnostic assay will refer back to the therapeutic with which the test is intended to be used. Herceptin treatment should only be initiated by a physician experienced in the administration of cytotoxic chemotherapy. On slidesfinder you get presentations from our huge library of professional ppt presentations. Herceptin is a medication approved for treating specific kinds of breast or stomach cancer. Herceptin complete drug facts, side effects and dosages. Administer according to one of the following doses and schedules for a total of 52 weeks of herceptin therapy.
Jun 22, 2012 adcc, antibodydependent cellmediated cytotoxicity. Her2 testing is mandatory prior to initiation of therapy see sections 4. Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. Trastuzumab is a humanized igg1 kappa monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 protein, her2.
However, it is not effective against several patients due to acquired or. Herceptin as a single agent is indicated for the treatment of patients with metastatic breast cancer whose tumors overexpress the. Trastuzumab herceptin trastuzumab, herzuma trastuzumab. Eligibility for herceptin treatment is determin ed by a diagnostic test, saving time from the outset. Schematic illustration showing the proposed mechanism of trastuzumab. See full prescribing information for complete boxed warning.
How to crop pictures in word, excel, and powerpoint 2010. This process will then insert a screenshot of your open pdf document window into the powerpoint presentation. Insert a pdf file as an object into a powerpoint presentation. Herceptin is a monoclonal antibody that binds to the extracellular portion of the her2 gene, preventing dimerization and the. Aug 19, 2019 slowly inject 20 ml of diluent into the vial with the stream of diluent directed into the lyophilized cake of trastuzumab. A markov healthstate transition model was constructed to simulate the natural development of breast cancer based on herceptin adjuvant hera trial. These patients did not receive her2targeted therapy. Herceptin trastuzumab, herceptin hylecta tm aetna precertification notification trastuzumab and hyaluronidaseoysk, 503 sunport lane, orlando, fl 32809. Find patient medical information for herceptin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This presentation contains certain forwardlooking statements. Herceptin and its biosimilars are monoclonal antibodies that selectively bind with high affinity to the her2 protein. Nurse guide for subcutaneous trastuzumab administration summary trastuzumab subcutaneous injection is given as a flat dose of 600mg5ml.
The needle should be held in place for 30 seconds before withdrawing withdraw the needle rapidly. Trastuzumab in female breast cancer patients with reduced. These forwardlooking statements may be identified by words such as believes, expects, anticipates, projects. Click on the thumbnail that shows your open pdf document to select it. Trastuzumab is given by slow intravenous iv infusion a method of putting. Highlights of prescribing information initial dose of 4. The package insert recommends assessing the lvef before initiation of herceptin. Herceptin is a drug used as adjuvant chemotherapy in cancer slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Insert pdf file content into a powerpoint presentation powerpoint. Herceptin trastuzamab in advanced breast cancer cancer. Highlights of prescribing information initial dose of 4 mg. The targeted therapy, considered a breakthrough when it was.
Herceptin resistance database for understanding mechanism. Herceptin is a sterile, white to pale yellow, preservativefree lyophilized powder for intravenous iv infusion. To show content from a pdf on a slide take a picture of the part of a pdf that you want, and paste it on your slide. Herceptin may be resumed if, within 48 weeks, the lvef returns to normal limits and the absolute decrease from baseline is. Australian product information herceptin sc trastuzumab. Oligohydramnios was accompanied by delayed development of the fetal kidneys, as well as some external, visceral, and skeletal abnormalities, seen in nearly all subjects. This part of the emedtv site offers an indepth look at herceptin, including how it works, when it is used, dosing. Insert the needle into the skin at an angle of 30 and release the grasped skin. Any changes you make to these geogebra materials are saved in your powerpoint. Thus, the current package insert for trastuzumab describes three categories of reactions that may be associated with trastuzumab infusions.
Herceptin may be resumed if, within 4 8 weeks, the lvef returns to normal limits and the absolute decrease from baseline is 15%. Contraception should be used while receiving herceptin and for 7 months after your last dose of herceptin. Safety data sheet herceptinr vials 440 mg section 1. Cost implications of using trastuzumab, as administered in the breast cancer. Herceptin can result in subclinical and clinical cardiac failure manifesting as chf. It may be used by itself or together with other chemotherapy medication. If you are or become pregnant while receiving herceptin or within 7 months after your last dose of herceptin, you should immediately report herceptin. Download, view or print all the forms and documents you need to get started with herceptin access solutions, including enrollment forms, tips and checklists. This study compared the incidences of left ventricular ejection fraction declines and heart failure with trastuzumab therapy in female breast cancer patients with normal or abnormal cardiac function at baseline, based on a left ventricular ejection fraction cutoff of normal at. This part of the emedtv site offers an indepth look at herceptin, including how it works, when it is used, dosing information, and possible side effects. When this agent was introduced as adjuvant therapy, the trastuzumab herceptin prescribing information package insert closely followed the recommendations for suspension of trastuzumab used in these pivotal clinical trials. Herceptin 600 mg solution for injection in vial summary of.
This emedtv resource describes in more detail how herceptin works to combat certain types of breast or stomach cancer, and explains herceptin uses in children. Feb 17, 2014 thus, the current package insert for trastuzumab describes three categories of reactions that may be associated with trastuzumab infusions. Slidesfinder is a sharing website for powerpoint presentations search and share. Highlights of prescribing information initial dose of. A new subcutaneous formulation of trastuzumab herceptin, genentechroche has been approved by the european commission. Using a sterile syringe, slowly inject the 20 ml of diluent into. The summary of product characteristics recommends observation for 6 hours after the commencement of the first administration. An economic evaluation of adjuvant trastuzumab therapy in her2. Find your interest in the form of powerpoint presentations on slidesfinder and save your valuable time.
Like trastuzumab, pertuzumab was among the firstline antiher2 antibodies tested preclinically in vitro and in vivo that showed that antibodies against the her2 extracellular domain could growthinhibit these tumors preclinically. Identification of the substancemixture and of the companyundertaking 1. Herceptin is available as a singledose vial containing 60 mg or 150 mg of trastuzumab. Herceptin and its biosimilars are mediators of antibodydependent cellular cytotoxicity adcc. Occasionally, the package insert component of product labeling for drugs that have received fda approval for commercial use is prefaced by prominent precautionary and warning summaries. Incidence, risk factors, and management of infusionrelated. If you are or become pregnant while receiving herceptin or within 7 months after your last dose of herceptin, you should immediately report herceptin exposure to. Like trastuzumab, pertuzumab was among the firstline antiher2 antibodies tested preclinically in vitro and in vivo that showed that. Trastuzumab is given by slow injection into a vein and injection just under the skin. Insert pdf file content into a powerpoint presentation. Herceptin resistance database for understanding mechanism of. Herceptin hylecta can result in subclinical and clinical cardiac failure.
Drug preparation and administration hematologyoncology. Fulltext pdf a phase iii study comparing sb3 a proposed trastuzumab biosimilar and trastuzumab reference product in her2. The nominal content of each herceptin vial is 440 mg trastuzumab, 9. A, oneyear survival in women with metastatic breast cancer receiving trastuzumab versus 1year survival after a diagnosis of heart failure. Current status of companion and complementary diagnostics. Dailymed herceptin trastuzumab kit herceptin trastuzumab. Trastuzumab herceptin trastuzumab, herzuma trastuzumab pkrb, kanjinti trastuzumab anns, ogivri trastuzumab dkst, ontruzant trastuzumab dttb, trazimera trastuzumab qyyp these. Herceptin is available as a singledose vial containing 60 mg or 150 mg of trastuzumab with the following excipients. An economic evaluation of herceptin in adjuvant setting. The current herceptin package insert is enclosed for your reference. Herceptin trastuzumab is a recombinant dnaderived humanized monoclonal antibody that selectively binds with high affinity in a cellbased assay kd 5 nm to the extracellular. A p185, a product of the neu protooncogene, is a receptorlike protein associated with tyrosine kinase activity. Herceptin may result in the death of an unborn baby or birth defects.
It is used to treat a type of breast cancer that produces a specific receptor known as her2. Interactive learning, teaching and evaluation resources created with geogebra can be shared and used by everyone at the geogebra app for powerpoint lets you insert interactive geogebra materials into your presentation. This emedtv resource describes in more detail how herceptin works to combat certain types of breast or stomach cancer, and explains herceptin. Inject the drug slowly 2 5 minutes injecting medication into compressed tissue irritates nerve fibres and causes the patient discomfort ostendorf 2011. It is supplied as a nonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. It is further recommended that trastuzumab be permanently discontinued for persistent 8 weeks lvef declines or trastuzumab. Trastuzumab can be resumed if, within 4 to 8 weeks, the lvef returns to normal or the absolute decrease is. Herceptin 600 mg solution for injection in vial summary.
Trastuzumab is a drug used to treat a type of breast cancer called her2 positive. During and following paclitaxel, docetaxel, or docetaxelcarboplatin. Compendia recommended indications her2positive overexpression criteria. If so, share your ppt presentation slides online with. Herceptin is marketed in the united states by genentech, in japan by chugai and internationally by roche.
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